Biomaterials carrying cyclodextrins having improved absorption properties and used for the progressive and delayed release of therapeutic molecules
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United States of America Patent
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Dec 9, 2014
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Nov 15, 2005
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Nov 15, 2004
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Abstract
A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial:
- a) application of a solid mixture of: cyclodextrin(s) and/or cyclodextrin derivative(s) and/or cyclodextrin inclusion complex(es) and/or cyclodextrin derivative inclusion complex(es),at least one poly(carboxylic) acid,and optionally a catalyst; b) heating at a temperature between 100° C. and 200° C. for a period of 1 to 60 minutes;c) washing with water;d) drying,wherein at least one bioactive agent is incorporated in the biomaterial by impregnation of the biomaterial after the drying step in a concentrated solution of the bioactive agent.
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