Pharmaceutical composition in which solubility of partially soluble tricyclic derivative is improved
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United States of America Patent
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Dec 9, 2014
Grant Date -
Apr 25, 2013
app pub date -
Jun 23, 2011
filing date -
Jun 25, 2010
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Abstract
A pharmaceutical composition includes lipid nanoparticles which include two or more of a phospholipid, cholesterol, and an ionic lipid, and a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. It is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.
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