Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes

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United States of America Patent

PATENT NO 8906354
SERIAL NO

13043057

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Abstract

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The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.

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Patent Owner(s)

  • BRUKER BIOSPIN CORPORATION

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bennett, James R Rochester, US 39 709
Harder, John W Rochester, US 45 296
Harrison, William J Pittsford, US 45 1361
Ji, Tao Hamden, US 42 88
Kelley, Brian J Farmington, US 7 115
Leon, Jeffrey W Placentia, US 49 483
Schmitthenner, Hans F Rush, US 12 15
Stegman, David A Churchville, US 23 211
Wang, Ruizheng Rochester, US 38 176
Yang, Yonghong Hamden, US 37 711

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