Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders
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United States of America Patent
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Nov 11, 2014
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app pub date -
Nov 20, 2008
filing date -
Nov 21, 2007
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Abstract
The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I:
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