Pegylated cyclopamine analogue, preparation method and uses thereof

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United States of America Patent

PATENT NO 8877928
SERIAL NO

13882797

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Abstract

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A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.

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Patent Owner(s)

Patent OwnerAddress
SHANDONG UNIVERSITY264209 NO 180 WENHUA WEST ROAD SHANDONG WEIHAI WEIHAI CITY SHANDONG PROVINCE 264209
BEIJING KEMEDICINE CO LTD102206 NO 31 SCIENCE ROAD BEIJING CHANGPING DISTRICT BEIJING CITY BEIJING CITY 102206

International Classification(s)

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  • 2011 Application Filing Year
  • A61K Class
  • 10915 Applications Filed
  • 8360 Patents Issued To-Date
  • 76.60 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hu, Zhao Beijing, CN 12 23
Song, Chun Shandong, CN 4 2
Sun, Zhijun Beijing, CN 11 264
Wang, Mingyi Beijing, CN 6 49
Xu, Xiuling Beijing, CN 2 3
Zhang, Chengzhi Beijing, CN 143 819
Zhang, Youzhong Beijing, CN 2 0
Zhao, Xin Beijing, CN 1071 7724

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  • A61K Class
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1767499999127813872291511752101 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0250500750100012501500175020002250250027503000325035003750400042504500475050005250

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