Device for examining myocardial toxicity, chip for examining myocardial toxicity and method for examining myocardial toxicity
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United States of America Patent
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Nov 4, 2014
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app pub date -
Dec 4, 2009
filing date -
Dec 5, 2008
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Abstract
Provided is a device and a method for examining myocardial toxicity, which can be realized in vitro in an equivalent manner as those conventionally carried out in vivo. A cell population as a pulsating pacemaker is arranged on a transparent substrate. Myocardial pulsating cells are arranged while being spaced apart appropriately. Fibroblast cells are arranged with/connected to the myocardial pulsating cells to form a cell network. Each of the myocardial pulsating cells and fibroblast cells forming the network is arranged on a transparent electrode provided on the transparent substrate. The cells forming the network are exposed to a flow of a solution containing a drug and QT delay due to the drug is evaluated.
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