Rage fusion proteins and methods of use

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United States of America Patent

PATENT NO 8877192
SERIAL NO

12983604

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Abstract

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Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.

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Patent Owner(s)

Patent OwnerAddress
VTVX HOLDINGS I LLC4170 MENDENHALL OAKS PKWY HIGH POINT NC 27265

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mjalli, Adnan M M Oak Ridge, US 93 1556
Rothlein, Robert Summerfield, US 41 496
Tian, Ye Edward Jamestown, US 36 122
Webster, Jeffrey C Jamestown, US 14 115

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