Method for purifying Ceftizoxime sodium

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United States of America Patent

PATENT NO 8871927
SERIAL NO

14008541

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Abstract

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A novel process for refining Ceftizoxime sodium compound, comprises the steps of: 1) dissolving crude Ceftizoxime sodium in water, and extracting with cyclohexane or ethyl acetate, followed by separating the organic phase containing impurities, producing an aqueous phase containing Ceftizoxime sodium; 2) adding ammonia or ammonium hydroxide into the above aqueous phase while stirring, followed by filtrating the precipitate, producing an aqueous filtrate containing Ceftizoxime sodium; 3) adding an alcoholic solvent in the aqueous solution and recrystallizing under controlled temperature, followed by centrifuging and washing the resultant crystals, producing the refined Ceftizoxime sodium after drying; and 4) optionally returning the mother liquid of the recrystallization process to step 3).

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Patent Owner(s)

Patent OwnerAddress
YINING AIERXING INTELLETUAL PROPERTY SERVICE CO LTDROOM 352 BUILDING B NO 1 NINGYUAN ROAD YINING PARK ECONOMIC DEVELOPMENT ZONE HORGOS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Tao, Linggang Wuyi, CN 15 0

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