Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
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United States of America Patent
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Oct 21, 2014
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Jun 5, 2012
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Jun 6, 2011
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Abstract
Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2α) and thereby provide a method for treating cancer. Further disclosed are compositions which comprise {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and/or a prodrug thereof which can be used to treat cancer.
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