Signature for the diagnosis of cancer aggressiveness and genetic instability
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United States of America Patent
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Oct 21, 2014
Grant Date -
Jan 26, 2012
app pub date -
May 18, 2011
filing date -
Nov 13, 2009
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Abstract
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in the patient cancer sample, calculating an expression level ratio of the expression level of POLQ to the expression of the control gene in the patient cancer sample, comparing the expression level ratio to a corresponding threshold value, and diagnosing cancer aggressiveness and genetic instability if the POLQ expression level ratio is superior to a corresponding threshold value. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
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