Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents

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United States of America Patent

PATENT NO 8865223
SERIAL NO

12867215

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Abstract

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Nanoparticulate assemblies of isolated beta-casein, are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. These nano-sized beta-casein assemblies are preferably formed at pH values which are at least one or more pH units below or above the pI of the protein. Pharmaceutical compositions comprising the beta-casein micelles may be used to administer the agents to the GI tract for treatment of local or systemic conditions. These carriers are stable over a wide temperature range (optionally at least from about 1° C. to at least about 45° C.).

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Patent Owner(s)

Patent OwnerAddress
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTDTECHNION CITY CANADA BLDG HAIFA 320003

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barenholz, Yechezkel Jerusalem, IL 94 1439
Danino, Dganit Nesher, IL 3 10

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