Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
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United States of America Patent
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Oct 14, 2014
Grant Date -
May 22, 2014
app pub date -
Nov 19, 2012
filing date -
Nov 19, 2012
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Abstract
A hydrogel tissue adhesive having decreased gelation time and decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide containing aldehyde groups with a water-dispersible, multi-arm amine in the presence of a thiol additive. The thiol additive accelerates the process to form the hydrogel and accelerates the degradation of the hydrogel formed. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.
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