Vaccinia virus mutants containing the major genomic deletions of MVA
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United States of America Patent
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Oct 14, 2014
Grant Date -
Dec 6, 2012
app pub date -
Jan 28, 2011
filing date -
Jan 28, 2010
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Abstract
The present invention provides modified vaccinia virus (VACV) genomes as well as vectors, especially viral vectors comprising the same. The present invention further provides modified vaccinia viruses. The present invention further provides methods for determining the effect of mutations in VACV with regard to competence for replication in certain cell types. The present invention further provides methods of preparing modified vaccinia viruses.
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