Method for protection of peptides or proteins against non-enzymatic deamidation
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United States of America Patent
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Oct 14, 2014
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app pub date -
Dec 19, 2008
filing date -
Dec 21, 2007
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Abstract
Stabilization of water-containing solutions or lyophilizates of proteins and peptides against non-enzymatic deamidation degradation reactions at asparaginyl or glutaminyl residues is achieved using organic anions, such as saccharin, benzenesulfonic acid, gentisic acide or N-acetyltryptophan which have a pKa within the range of 0.5 to 3.5.
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