Agents for treating disorders involving modulation of ryanodine receptors
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United States of America Patent
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Oct 7, 2014
Grant Date -
Mar 27, 2014
app pub date -
Nov 11, 2013
filing date -
Apr 18, 2012
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Abstract
The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.
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