Microarrays of binary nucleic acid probes for detecting nucleic acid analytes

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United States of America Patent

PATENT NO 8853134
APP PUB NO 20120040867A1
SERIAL NO

13146626

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Abstract

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Some embodiments of the invention are directed to a microarray of binary nucleic acid probes for the detection of one or a plurality of nucleic acid analytes in a complex sample in a single high throughput assay with extraordinary specificity under physiologic conditions. Any binary nucleic acid probes that generate a detectable signal when bound to analyte are suitable for use in the microarrays, including binary deoxyribozyme or ribozyme probes; nonenzymatic binary probes for fluorescent detection, nonenzymatic binary dye-binding probes, and binary split enzyme peroxidase probes for visual detection of nucleic acids. The invention is also directed to new non nonenzymatic binary probes that bind to reporter oligonucleotides.

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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK535 WEST 116TH STREET NEW YORK NY 10017

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kolpashchikov, Dmitry Winter Park, US 6 20

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