N-acetylglucosamine-2-epimerase and method for producing CMP-neuraminic acid using the same
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United States of America Patent
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Oct 7, 2014
Grant Date -
Nov 24, 2011
app pub date -
Dec 7, 2007
filing date -
Dec 15, 2006
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Abstract
The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.
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