Method for identifying an antagonist of guanine nucleotide releasing factor 1
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United States of America Patent
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Oct 7, 2014
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Aug 3, 2011
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Aug 10, 2000
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Abstract
The invention concerns the use of whole or part of the GRF1 protein, or of cells expressing whole or part of the GRF1 protein, in methods for detecting compounds for preventing and/or treating pathologies or disorders of the central nervous system involving neuronal death, such as apoptosis, or related to leptin metabolism. The pathologies of the central nervous system are in particular cerebral ischemia, Parkinson's disease or Alzheimer's disease.
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