Cardiac muscle regeneration using mesenchymal stem cells
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United States of America Patent
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Oct 7, 2014
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Feb 9, 2012
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Jul 14, 1997
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Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectable or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.
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