Therapeutic uses of steroidal compounds
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United States of America Patent
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Sep 30, 2014
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app pub date -
Nov 17, 2006
filing date -
Nov 18, 2005
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Abstract
A steroid derivative compound of formula (I) in which: one of R1 and R2 is hydroxy and the other is hydrogen; or R1 and R2 together represent oxo; R3 is hydrogen or hydroxy; and the dotted lines represent single or double carbon-carbon bonds; and pharmaceutically acceptable salts and esters thereof are useful for the prevention or treatment of pain, for improving nerve regeneration after nerve injury or damage or disease, for the prevention or treatment of brain injury, damage or disease and for neuroprotection. Particularly useful compounds are 11-hydroxy-Δ4-androstene-3,17-dione and 11-oxo-Δ4-androstene-3,17-dione or their derivatives.
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