Derivatives, reagents, and immunoassay for detecting levetiracetam
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United States of America Patent
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Sep 30, 2014
Grant Date -
Dec 16, 2010
app pub date -
Jun 9, 2010
filing date -
Jun 11, 2009
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Abstract
Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivatives can include operative groups, such as: immunogenic moieties that can be used to prepare anti-LEV antibodies; antigenic moieties that can be used in immunodiagnostic assays for LEV; or tracer moieties that can be used in immunodiagnostic assays. Additionally, the LEV derivatives can be used in immunodiagnostic assays to compete with LEV for anti-LEV antibodies.
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