Nanoparticles and methods of use

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United States of America Patent

PATENT NO 8846096
APP PUB NO 20110236437A1
SERIAL NO

13132442

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are nanoparticles and methods for using nanoparticles. The nanoparticles include at least three antiretroviral agents. When introduced to cells the nanoparticles cause an increase in the intracellular concentration of the antiretroviral agents to a level that is at least the IC50 against HIV-I or HIV-2. This concentration may be maintained for at least 21 days after the cells are contacted with the nanoparticle. When administered to a subject the nanoparticles cause the concentration of the antiretroviral agents to increase to at least 100 ng/ml in the serum of the subject, at least 0.5 μg/gram tissue in an organ of the subject, or a combination thereof. Such a concentration may be maintained for at least 21 days after the administration.

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Patent Owner(s)

Patent OwnerAddress
CREIGHTON UNIVERSITY2500 CALIFORNIA PLAZALINN BUILDING L06 OMAHA NE 68178

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Destache, Christopher J Omaha, US 2 9

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