Hybrid cholinesterase inhibitors
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United States of America Patent
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Sep 23, 2014
Grant Date -
Mar 20, 2014
app pub date -
Nov 22, 2013
filing date -
Jun 3, 2011
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Abstract
The invention relates to novel hybrid cholinesterase inhibitors containing the melatonin or its oxidation products unit and tetrahydroacridine unit linked via a carbamate bond. Due to the high selectivity of action, which is expressed with high ratio of IC50 for acetylcholinesterase inhibition to IC50 for butyrylcholinesterase inhibition ([IC50(AChE)]/[IC50(BChE)]), the novel compounds may be used in relief and/or treatment of the neurodegenerative diseases, among them the Alzheimer's disease.
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