Fluorescence resonance energy transfer detection with nanoparticles for in vitro and in vivo applications
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United States of America Patent
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Sep 23, 2014
Grant Date -
Mar 5, 2009
app pub date -
Aug 29, 2008
filing date -
Apr 10, 2006
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Abstract
A combination of nanoparticles is disclosed comprised of amine functionalized polyethylene glycol in which one particle with a fluorescent donor dye having one wavelength excitation maximum and at least one additional particle with a second fluorescent dye having a second, higher wavelength excitation maximum, the particles having the same or different biomolecule targeting moieties bound to their external surfaces.
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