Vaccines against multiple subtypes of dengue virus
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United States of America Patent
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Sep 16, 2014
Grant Date -
Nov 18, 2010
app pub date -
Jan 12, 2009
filing date -
Jan 11, 2008
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Abstract
An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.
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