Compounds of the pterocarpanquinone family, method for preparing the same, pharmaceutical composition containing the new compounds of the pterocarpanquinone family, uses and therapeutic method

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United States of America Patent

PATENT NO 8835489
SERIAL NO

13127797

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Abstract

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This invention belongs to the chemical-pharmaceutical field. New compounds of pterocarpanquinone family presented in formula (I) according to this invention are capable to be activated by reduction generating alkylating species intracellularly. It presents selective cytotoxic effects particularly on mammalian human and nonhuman cells that divide constantly and are useful in treating diseases and dysfunctions related to the phenomenon of undesired cell proliferation. Such compounds are also effective for the treatment of diseases or dysfunctions related to high levels of TNF-α in human and nonhuman mammals.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDADE FEDERAL DO RIO DE JANEIROAV HORÁCIO MACEDO 2030-PRÉDIO DO CENTRO DE TECNOLOGIA BLOCO G SALA 101 CIDADE UNIVERSITÁRIA RIO DE JANEIRO 21941-914

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bergmann, Bartira Rossi Rio de Janeiro, BR 1 0
Cavalcante, Moises Clemente Marinho Rio de Janeiro, BR 1 0
Costa, Paulo Roberto Ribeiro Rio de Janeiro, BR 1 0
Da, Silva Alcides Jose Monteiro Duque de Caxias, BR 1 0
Dos, Santos Eduardo Caio Torres Rio de Janeiro, BR 1 0
Dos, Santos Eduardo Salustiano Jesus Rio de Janeiro, BR 1 0
Lima, Wallace Pacienza Rio de Janeiro, BR 1 0
Netto, Chaquip Daher Rio de Janeiro, BR 1 0
Rica, Ingred Goretti Rio de Janeiro, BR 1 0
Rumjanek, Vivian Mary Barral Dold Rio de Janeiro, BR 1 0
Seabra, Sergio Henrique Rio de Janeiro, BR 1 0

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