Cycloastragenol monoglucoside, preparation, pharmaceutical composition and application thereof
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United States of America Patent
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Sep 16, 2014
Issued Date -
N/A
app pub date -
Sep 8, 2008
filing date -
Sep 13, 2007
priority date (Note) -
In Force
status (Latency Note)
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Abstract
This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH | 300193 TIANJIN CITY NANKAI DISTRICT ANSHAN WEST ROAD NO 308 TIANJINCITY TIANJINCITY 300193 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Fu, Xiaoli | Tianjin, CN | 38 | 627 |
# of filed Patents : 38 Total Citations : 627 | |||
Han, Yingmei | Tianjin, CN | 3 | 8 |
# of filed Patents : 3 Total Citations : 8 | |||
Liu, Peng | Tianjin, CN | 833 | 6111 |
# of filed Patents : 833 Total Citations : 6111 | |||
Liu, Wulin | Tianjin, CN | 1 | 7 |
# of filed Patents : 1 Total Citations : 7 | |||
Tang, Lida | Tianjin, CN | 15 | 45 |
# of filed Patents : 15 Total Citations : 45 | |||
Wang, Weiting | Tianjin, CN | 7 | 12 |
# of filed Patents : 7 Total Citations : 12 | |||
Wang, Yuli | Tianjin, CN | 53 | 688 |
# of filed Patents : 53 Total Citations : 688 | |||
Xia, Guangping | Tianjin, CN | 4 | 11 |
# of filed Patents : 4 Total Citations : 11 | |||
Xu, Weiren | Tianjin, CN | 12 | 42 |
# of filed Patents : 12 Total Citations : 42 | |||
Zhang, Shijun | Tianjin, CN | 38 | 230 |
# of filed Patents : 38 Total Citations : 230 | |||
Zhao, Naxia | Tianjin, CN | 3 | 8 |
# of filed Patents : 3 Total Citations : 8 | |||
Zhao, Zhuanyou | Tianjin, CN | 2 | 7 |
# of filed Patents : 2 Total Citations : 7 |
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Mar 16, 2026 |
Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
---|---|---|---|
Aug 30, 2006 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Jul 28, 2006 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Jul 28, 2006 |
Jul 28, 2006 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | |
Feb 15, 2006 | REMI | MAINTENANCE FEE REMINDER MAILED | |
Dec 07, 2001 | FPAY | FEE PAYMENT | year of fee payment: 4 |
Jul 28, 1998 | I | Issuance | |
Feb 28, 1997 | F | Filing | |
Dec 28, 1993 | PD | Priority Date |

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