Cycloastragenol monoglucoside, preparation, pharmaceutical composition and application thereof

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United States of America Patent

PATENT NO 8835134
SERIAL NO

12678025

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Abstract

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This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.

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Patent Owner(s)

Patent OwnerAddress
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH300193 TIANJIN CITY NANKAI DISTRICT ANSHAN WEST ROAD NO 308 TIANJINCITY TIANJINCITY 300193

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fu, Xiaoli Tianjin, CN 38 627
Han, Yingmei Tianjin, CN 3 8
Liu, Peng Tianjin, CN 833 6111
Liu, Wulin Tianjin, CN 1 7
Tang, Lida Tianjin, CN 15 45
Wang, Weiting Tianjin, CN 7 12
Wang, Yuli Tianjin, CN 53 688
Xia, Guangping Tianjin, CN 4 11
Xu, Weiren Tianjin, CN 12 42
Zhang, Shijun Tianjin, CN 38 230
Zhao, Naxia Tianjin, CN 3 8
Zhao, Zhuanyou Tianjin, CN 2 7

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11.5 Year Payment $7400.00 $3700.00 $1850.00 Mar 16, 2026