Chimaeric protein
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United States of America Patent
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Sep 9, 2014
Grant Date -
Jul 12, 2012
app pub date -
Jul 5, 2010
filing date -
Jul 7, 2009
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Abstract
The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.
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