Nucleic acid molecule capable of binding to c-Met and use thereof
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United States of America Patent
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Sep 2, 2014
Grant Date -
May 16, 2013
app pub date -
Jul 26, 2011
filing date -
Jul 26, 2010
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Abstract
The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2).
- (A1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 1 to 38(A2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 1 to 38(B1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 39 to 76(B2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 39 to 76.
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