Peptides and aptamers thereof as specific modulators of mutant p53 function
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United States of America Patent
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Sep 2, 2014
Grant Date -
Oct 11, 2012
app pub date -
Mar 13, 2008
filing date -
Mar 13, 2008
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Abstract
In the present application isolated peptides and aptamers thereof able to interact with structural and conformational p53 mutants within the region of the wild-type p53 DNA binding core domain comprised from amino acids 74 to amino acids 298 using the yeast two-hybrid method are disclosed. These PAs are able to efficiently recognize several different p53 point mutants but not wild-type p53. Therefore the peptides and aptamers identified can be useful as inhibitors of mutant p53-associated pro-oncogenic functions for anticancer therapy or as diagnostic tools for mut-p53 or wild-type p53 or as template for designing new peptido-mimetic drugs able to specifically target tumor cells.
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