PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for treating type 2 diabetes mellitus
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United States of America Patent
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Aug 26, 2014
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May 23, 2013
app pub date -
Jul 7, 2011
filing date -
Aug 6, 2010
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Abstract
The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
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