Mitochondrial activity inhibitors of cancer-initiating cells and use thereof
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United States of America Patent
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Aug 26, 2014
Grant Date -
Mar 22, 2012
app pub date -
May 20, 2010
filing date -
May 20, 2009
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Abstract
The present invention relates to the compounds useful in the prevention and/or treatment of tumors. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumors presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumor glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.
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