Synthesis of cyclopentaquinazolines
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United States of America Patent
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Aug 19, 2014
Grant Date -
Aug 15, 2013
app pub date -
Jul 15, 2011
filing date -
Jul 19, 2010
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Abstract
A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).
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