Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases

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United States of America Patent

PATENT NO 8809350
APP PUB NO 20120309723A1
SERIAL NO

13464362

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Abstract

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The present invention relates to the use of an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for treating a disease associated with antinuclear antibodies, wherein the inhibitor of CDK2 and/or CDK7 and/or CDK9 or pharmaceutically acceptable salt thereof is administered in an amount sufficient to down-regulate the levels of antinuclear antibodies. A further aspect of the invention relates to a combination comprising an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, and methylprednisolone, and its use in the treatment of diseases associated with antinuclear antibodies, such as SLE.

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Patent Owner(s)

Patent OwnerAddress
CYCLACEL LIMITEDLONDON EC2Y 5AU

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benigni, Ariela Bergamo, IT 5 26
Gianella-Borradori, Athos Gauting, DE 9 53
Remuzzi, Giuseppe Bergamo, IT 10 28
Zoja, Carla Bergamo, IT 2 14

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