Manufacture of vaccines that contain both hepatitis B virus surface antigens and surfactant
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United States of America Patent
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Aug 12, 2014
Grant Date -
May 3, 2012
app pub date -
Nov 22, 2011
filing date -
Nov 8, 2005
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Abstract
When preparing HBsAg for use in a combination vaccine, it us known to add a non-ionic detergent after the HBsAg has been purified. Adding detergents after purification of HBsAg is not optimal, however, as it requires a separate processing step during manufacture. Thus the invention uses them during HBsAg purification.
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