Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods

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United States of America Patent

PATENT NO 8796432
APP PUB NO 20090263791A1
SERIAL NO

12084457

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Abstract

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This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue.

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Patent Owner(s)

Patent OwnerAddress
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK THEWEST 116TH STREET AND BROADWAY NEW YORK NY 10027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bi, Lanrong New York, US 16 850
Ju, Jingyue Englewood Cliffs, US 133 7472
Kim, Dae H New York, US 12 556
Meng, Qinglin Sunnyvale, US 34 1375

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