Methods for repressing B cell autoantibody secretion and for treating autoimmune disorders by administration of hematopoietic stem cells and macrophage-colony stimulating factor
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Aug 5, 2014
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Mar 15, 2006
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Sep 16, 2003
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Abstract
The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disorders using regulatory immune cells or precursors thereto such as hematopoietic stem cells (HSC). The invention also provides methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disorders by administration of HSC and Macrophage-Colony Stimulating Factor (M-CSF). Further provided are methods of diagnosing in a mammalian subject a defect in regulatory cell mediated repression of autoantibody secretion by B cells.
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