Complex of amorphous tomoxiprole and cyclodextrin with fast dissolution rate and process for the preparation thereof
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United States of America Patent
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Jul 29, 2014
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May 8, 2014
app pub date -
Jun 14, 2012
filing date -
Jul 1, 2011
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Abstract
A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorption with respect to crystalline tomoxiprole and is particularly suitable for the production of pharmaceutical oral dosage forms, such as tablets and capsules, where rapid onset of therapeutical action is required. A method of manufacture of the complex is also described and claimed.
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