Inhibition of SOX9 function in the treatment of proteoglycan-associated pathophysiological conditions
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United States of America Patent
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Jul 29, 2014
Grant Date -
Feb 4, 2010
app pub date -
Oct 25, 2007
filing date -
Oct 27, 2006
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Abstract
A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.
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