Methods of using proteinacious channels to identify pharmaceutical treatments and risks, and treatments resulting therefrom
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United States of America Patent
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Jul 22, 2014
Grant Date -
May 6, 2010
app pub date -
Oct 30, 2009
filing date -
Oct 31, 2008
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Abstract
Methods and therapeutic strategies utilizing proteinacious channels in lipid membranes of mammalian cells. The methods entail administering a pharmaceutical to a lipid membrane of a mammalian cell, and then determining the effect of the pharmaceutical on the electrophysiology of at least one vascular proteinacious channel of the lipid membrane, wherein the vascular proteinacious channel is a vascular Kv7 potassium channel and/or a vascular L-type calcium channel. The method can be used to identify pharmaceuticals that may be used to treat hypertension and/or vasospastic conditions, or to perform drug screening to assess potential cardiovascular risk of pharmaceuticals.
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