Peptide synthesis
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United States of America Patent
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Jul 22, 2014
Grant Date -
Feb 17, 2011
app pub date -
May 19, 2010
filing date -
Jun 1, 2009
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Abstract
A process for producing an insulin type peptide, for example a relaxin, involving oxidizing a methionine residue on a B-chain having cysteine residues and combining the B chain with an A chain having cysteine residues to form a peptide having intermolecular disulphide links and biological activity. Novel synthetic relaxin 1 and methionine oxidized relaxins and Met(O) B-chains having enhanced solubility are disclosed.
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