Inhibitors of mammalian tight junction opening
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United States of America Patent
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Jul 22, 2014
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Oct 20, 2008
filing date -
Oct 19, 2007
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Abstract
The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention.
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