Homogeneous vaccine composition comprising a conjugate of EGF and P64K for the treatment of tumors

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United States of America Patent

PATENT NO 8778879
APP PUB NO 20100196412A1
SERIAL NO

12664545

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Abstract

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The present invention concerns the biotechnology sector and more specifically human healthcare. In particular, the present invention describes a vaccine composition for therapeutic use thereof on cancer patients. The vaccine composition described in the present invention has as active principle a chemical conjugate of human recombining Epidermic Growth Factor (hrEGF) and are combining protein P64k. In addition, specific conditions are described for performing a conjugation reaction which produces said chemical conjugate in a controlled and reproducible manner. In another embodiment, the present invention concerns a method for purification of the chemical conjugate which not only provides greater purity for the therapeutic composition, but surprisingly increases the immunogenic activity causing significant increases in the anti-EGF antibody titers in humans. In addition, the present invention provides the methodology for producing a vaccine preparation with more than one type of dose presentation (total milligrams of conjugates/vial). This versatility in the presentation of the vaccine preparation enables the immunization dose per patient to be increased, but without involving an increase in immunization frequency and/or the number of immunization sites. The present invention involves a healthcare method for producing the vaccine for cancer therapy, administered by parenteral means.

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Patent Owner(s)

Patent OwnerAddress
CENTRO DE INMUNOLOGIA MOLECULAR (CIM)11600 CIUDAD DE LA HABANA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Albisa, Novo Airama Ciudad de la Habana, CU 1 0
Calvo, González Loany Ciudad de la Habana, CU 1 0
Chico, Véliz Ernesto Ciudad de la Habana, CU 1 0
Crombet, Ramos Tania Ciudad de la Habana, CU 5 1
Cuevas, Fiallo Ariadna Ciudad de la Habana, CU 2 0
González, Marinello Gisela Maria Ciudad de la Habana, CU 1 0
Lage, Dávila Agustín Bienvenido Ciudad de la Habana, CU 3 2
Rodríguez, Martínez Gryssell María Ciudad de la Habana, CU 1 0
Viña, Rodríguez Lisel Ciudad de la Habana, CU 1 0

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