Modified gram-negative bacteria for use as vaccines

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United States of America Patent

PATENT NO 8778655
SERIAL NO

13496007

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Abstract

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The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.

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UNIVERSIDAD DE NAVARRA31009 PAMPLONA (NAVARRA)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arce, Gorvel Vilma Marseilles Cedex, FR 2 9
Conde-Alvarez, Raquel Pamplona, ES 2 9
Gorvel, Jean-Pierre Marseilles Cedex, FR 4 12
Iriarte, Maite Pamplona, ES 2 9
Moriyon, Ignacio Pamplona, ES 2 9

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