Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system
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United States of America Patent
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Jul 15, 2014
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Jul 22, 2010
app pub date -
Jan 12, 2010
filing date -
Jan 12, 2009
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Abstract
This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.
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