Targeted delivery of siRNA
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United States of America Patent
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Jul 8, 2014
Grant Date -
Aug 19, 2010
app pub date -
Jan 25, 2008
filing date -
Jan 26, 2007
priority date (Note) -
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Abstract
The present invention provides a method of delivering RNA interference molecules to a cell or a cell in a subject, which comprises contacting the cell with a protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a protein, the protein comprising (1) a targeting moiety, which will specifically bind to a site on a target cell, and (2) a binding moiety linked thereto, which will bind to the double stranded RNA, wherein the double stranded RNA segment is delivered to a cell and effects RNA interference of the target RNA in the cell.
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