Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same
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United States of America Patent
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Jul 8, 2014
Grant Date -
Jun 14, 2012
app pub date -
Apr 21, 2011
filing date -
Apr 21, 2010
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Abstract
The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.
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