Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process
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United States of America Patent
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Jul 1, 2014
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Nov 7, 2013
app pub date -
Jul 1, 2013
filing date -
Sep 12, 2006
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Abstract
A docetaxel inclusion complex having improved water-solubility (up to 15 mg/ml) and stability (stability constant Ka=2056 M−1-13051 M−1), comprises docetaxel and hydroxypropyl-beta-cyclodextrin and/or sulfobutyl-beta-cyclodextrin in a ratio of 1:10-150. The method includes steps as follows: docetaxel dissolved in ethanol is added into water solution of cyclodextrin via stirring, until docetaxel is completely dissolved; said solution is filtered in 0.2-04 μm microporous membrane then ethanol is removed through reduced pressure to obtain the inclusion complex in a liquid form; or ethanol, followed by water is removed through reduced pressure, then dried to obtain the inclusion complex in a solid form.
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