Method for preparing pharmaceutical compositions comprising fine particles of active substance
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United States of America Patent
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Jul 1, 2014
Grant Date -
Jan 26, 2012
app pub date -
Mar 30, 2010
filing date -
Mar 31, 2009
priority date (Note) -
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Abstract
The present invention relates to a method for preparing solid pharmaceutical compositions comprising fine particles of at least one active substance, dispersed on and (or) within a divided solid. This method is characterized in that a solution is formed which comprises at least one active substance in a fluid at supercritical pressure, said solution then being expanded in a chamber under temperature and pressure conditions for which a part of said fluid is in the liquid state at the time of the expansion, said fluid thus expanded being brought into contact with a divided solid in said chamber.
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