Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

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United States of America Patent

PATENT NO 8759583
APP PUB NO 20130066111A1
SERIAL NO

13666239

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Abstract

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The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:

    a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionallyb) isolating the obtained sulphoxide of formula (I).

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Patent Owner(s)

  • TEVA SANTE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Courvoisier, Laurent Thorndale, US 22 78
Duret, Gerard Boulogne, FR 7 16
Graf, Stephanie Belloy en France, FR 7 11
Prat-Lacondemine, Laurence Pontault Combault, FR 3 2
Rebiere, Francois Antony, FR 6 15
Sabourault, Nicolas Paris, FR 2 1

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